What to know about Cushing’s syndrome, which led to Amy Schumer’s dramatic weight loss

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ComedianAmy Schumer, 44, has recently come clean about her struggle with Cushing’s syndrome, leading to a dramatic weight loss.

Schumer’s transformation has sparked conversation online, to which she responded in a now-deleted Instagram post that shut down speculation aboutcosmetic enhancements.

“I didn’t lose 30lbs — I lost 50,” she emphasized on social media, adding that she does not get Botox or filler.

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Schumer doubled down thather weight losswas not about her appearance, but about staying alive.

“Not to look hot, which does feel fun and temporary,” she said.“I did it to survive.I had a disease that makes your face extremely puffy that can kill you, but the internet caught it and that disease has cleared.”

side by side photo of amy schumer before and after weight loss

Amy Schumer attends Variety’s 2024 Power of Women: New York event on May 2, 2024, in New York City on the left.On the right, Schumer later poses for a photo posted to Instagram after her weight loss.(Marleen Moise/WireImage;Amy Schumer/Instagram)

“Sorry for whatever feeling it’s giving you that I lost that weight,” she added.“I’ve had plastic surgery over the years and I use [Mounjaro].Sorry to anyone they let down.I’m pain free.I can [play] tag with my son.”

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The actress also addressed her shifting hormones, saying that she’s “happy to share more if anyone has any questions about how I’m looking or feeling or where I am in myperimenopause process.”

A tan background filled with long paragraphs of vertically rotated white text from a now-deleted post from Amy Schumer.

“I didn’t lose 30lbs — I lost 50,” Schumer emphasized on social media, adding that she does not get Botox or filler.(Amy Schumer/Instagram)

What is Cushing’s syndrome?

Schumer previously revealed that she was diagnosed withCushing’s syndrome, a hormonal disorder that can cause extreme swelling, fatigue and potentially fatal complications.

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Dr.

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“Cushing’s syndrome is caused by prolonged, high exposure to cortisol, which is your body’s main stress hormone,” he said.“Usually, the excess cortisol is a result of prolonged steroid use.We see this many times with patients who have some autoimmune disorder.”

Balazs said the “key” to Cushing’s syndrome is not justweight gain, but a “specific redistribution” of fat caused by too much cortisol.

Split photos of Amy Schumer as a guest during a late-night talk show interview and another showing her walking outdoors in midtown Manhattan.

Amy Schumer is photographed during a guest interview on The Tonight Show Starring Jimmy Fallon on Feb.13, 2024 (left), and later seen walking through midtown New York City on Oct.28, 2025 (right).(Todd Owyoung/NBC via Getty Images;Raymond Hall/GC Images/Getty Images)

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Fat may be driven to the abdomen, chest, upper back (referred to as a “buffalo hump”) or the face, sometimes considered “moon face,” the doctor said.

Cortisol also breaks down protein, which leads to a thinning in the arms and legs.“Weight gain can be tough, involuntary and hard to manage,” Balazs added.

high blood pressure, bone loss and sometimes type 2 diabetes, per Mayo Clinic.

In addition to weight gain in certain areas, other symptoms may include pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms, as well as acne, slow wound healing, and thin, frail skin that bruises easily.

hump on the back of a man

With Cushing’s syndrome, fat may accumulate in the abdomen, chest, face or upper back (referred to as a “buffalo hump”).(iStock)

Women with Cushing’s syndrome often experience thick, dark hair on the face and body, as well as irregular periods.Symptoms among men can include a lower sex drive, reduced fertility and erectile dysfunction.

Mayo Clinic listed other potential symptoms, includingextreme fatigue, muscle weakness, depression, anxiety, irritability, mood swings, trouble with concentration and memory, headache, sleeplessness, skin darkening and stunted growth in children.

taking steroidsto treat health issues like asthma, arthritis or inflammatory bowel disease, as these medications can exacerbate the condition.

Mayo Clinic has reported that the “sooner treatment starts, the better the chances for recovery.”

pharmacist holds up two boxes of Mounjaro

“I’ve had plastic surgery over the years and I use [Mounjaro],” Schumer stated in a social media post.(George Frey/Bloomberg)

For patients like Schumer, weight loss is typically not the main goal, Balazs noted, but it is a “critical sign” ofsuccessful treatment.

“The primary goal is to normalize your high cortisol levels,” he said.“I believe Amy Schumer got treated first for her underlying problem.Once the cortisol is normalized, which is the most important step, there’s a role to use adjunct medications to decrease weight.”

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Among GLP-1s, Mounjaro is an “excellent choice to decrease deep belly fat andincrease insulin sensitivityof cells,” Balazs added.

�s Stephanie Giang-Paunon contributed to this report.

�s rep requesting comment.

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