Type 1 diabetes reversed in landmark study, paving the way for human studies

Researchers detailed how type 1 diabetes occurs when the immune system “mistakenly destroys insulin-producing islet cells in the pancreas.”(iStock)

The researchers’ goal was to create a “mixed chimerism” — an environment where the mouse has both its own cells and donor immune cells.

This method prevented the development of diabetes in all 19 pre-diabetic mice, as published in the Journal of Clinical Investigation.

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The researchers also studied nine mice that had long-standing type 1 diabetes.All nine of the mice were cured by the combined stem cell and islet transplantation.

The results did not indicate anymajor side effectsor immunity depletion, the scientists noted.

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Although this study was only done in mice and required some radiation, which could be limiting in future research, the experts shared their optimism that the treatment could eventually be applied to humans.

In addition to diabetes, this “gentler pre-conditioning approach” could make stem cell transplants a “viable treatment for autoimmune disease such asrheumatoid arthritisand lupus, and non-cancerous blood conditions like sickle cell anemia,” the researchers wrote.

All of the mice included in the study were cured of type 1 diabetes, the researchers reported.(iStock)

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“The key steps in our study — which resulted in animals with a hybrid immune system containing cells from both the donor and the recipient — are already being used in the clinic for other conditions,” study co-author Seung K.Kim, M.D., Ph.D., the KM Mulberry Professor and a professor of developmental biology, gerontology, endocrinology and metabolism at Stanford University, wrote in a statement.

organ transplants.”

“We believe this approach will be transformative for people with type 1 diabetes or other autoimmune diseases,” wrote the study co-author.(iStock)

�preliminary work,” it could show promise for humans.

genetic analysisand artificial intelligence for a personalized approach to autoimmunity, which causes type 1 diabetes,” he said.“It’s not one-size-fits-all.”