Brain aging may accelerate after cancer treatment, study suggests

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Surviving canceras a childor young adult may have a lasting impact on aging, new research suggests.

Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, likechemotherapy and radiation, could speed up biological aging.

They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.

The team analyzed blood samples from a group of 1,400 long-term survivors treated at St.Jude Children’s Research Hospital, usingepigenetic clocks— tools that estimate biological age by examining chemical tags on DNA.

Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.

Closeup of young people holding hands in hospital

Biological age is determined based on the damage cells accumulate over time, according to scientists.(iStock)

“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.

Most of the group consisted of acute lymphoblastic leukemia survivors, orHodgkin lymphoma survivors.Participants were at least five years past their treatment, though some had survived for several decades.

They underwent neurocognitive testing to measure their attention span, memory and information processing speed.

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Chemotherapy was found to have the greatest impact on aging acceleration.The study suggests the treatment can alterDNA structureand cause cellular damage.

Close-up showing doctor holding MRI brain scan of head and skull.

Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing.(iStock)

Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.

“Chemo poisons and damages cellular function — hopefully thecancer cellsmore than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.

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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.

The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.

quality of life.”

Young girl covering her head after being treated for cancer

The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline.(iStock)

There were some limitations to the study.The researchers could not adjust for chronichealth conditionsor education because they are directly impacted by treatment.

Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.

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The study was published in the journal Nature Communications.