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The world’s first GLP-1 weight loss treatment is beingadministered for petson an experimental basis.
The first cat was successfully dosed in the MEOW-1 study of OKV-119 – an investigational “ultra-long acting” GLP-1 implant, which, according to a press release, is being developed for weight management in cats.
OKAVA Pharmaceuticals, the San Francisco-based manufacturer of the medication, said the landmark clinical study of the “first-in-class” device could have “profound” implications for diabetes, kidney disease,healthy agingand longevity in pets.
delivery of the medicationfor up to six months.
The OKV-119 implant guarantees administration of the drug for six months.(iStock)
The MEOW-1 trial marks the first of its kind for clinical investigation ofweight lossin cats and dogs, following the breakthrough of GLP-1 use in humans for the management of obesity and diabetes.
OKAVA CEO Michael Klotsman, Ph.D., wrote in a statement that caloric restriction, or fasting, is “one of the most well-established interventions forextending lifespanand improving metabolic health in cats.”
improved insulin sensitivity, reduced fat mass and more efficient energy metabolism — without requiring significant changes in feeding routines or disruption of the human-animal bond that often centers around food.”
Future research will consider weight management in dogs, the researchers said.(iStock)
The MEOW-1 study aims to evaluate the safety, tolerability and efficacy of the weight-loss medication in overweight or obese cats.The results will guide future clinical development, as well as a similar study in dogs, according to the researchers.
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Dr.W.Chris Hummel, a veterinarian at Lovet Pet Health Care in Phoenix, Arizona, who was not involved in the study, confirmed that several GLP-1 drugs are under investigation in domestic animals.
A GLP-1 treatment for cats does not require changes in feeding that may disrupt human-animal bonding, the researchers stated.(iStock)
“Preliminary evidence suggests that GLP-1 and GLP-like drugs can be effectivealternative therapiesfor diabetes mellitus, otherwise known as sugar diabetes,�“Diabetes mellitus is one of the fastest-growing diseases in cats and dogs, largely on the heels of the pet obesity epidemic.”
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“The medications are given by injection, so long-acting combinations are currently being investigated for efficacy and duration,” Hummel added.“The data is still early, but promising.”
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