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A new, stronger flu shot could slash Alzheimer’s risk in half, according to new data.
The study, led by researchers at the University of Texas Health Science Center at Houston (UTHealth), found that adults 65 and older who received ahigh-dose influenza vaccinehad a significantly lower risk of developing Alzheimer’s disease compared to those who received the standard dose.
The immune system naturally weakens with age, making older adults less responsive to standard vaccines.To combat this, the Centers for Disease Control and Prevention recommends a high-dose flu vaccine for people over 65.This version is approximately four times stronger than the standard shot.
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Alzheimer’s disease, a brain disorder that slowly destroys memory and thinking skills, affects more than 6 million Americans, most of them age 65 or older.
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Alzheimer’s disease, a brain disorder that slowly destroys memory and thinking skills, affects more than 6 million Americans, most of them age 65 or older.(iStock)
As the vaccine directly affects the immune system, it is possible that this interaction could decrease inflammation in the body and “thereby indirectly decrease Alzheimer’s risk,�
“Flu shots and their components do not cross theblood-brain barrier, meaning they aren’t directly affecting brain cells.”
“We can’t conclude from this that it is the flu shot itself that causes the effect.”
“I was stunned that, as a physician, I didn’t know a higher dose was offered,” lead study author Paul Schulz, professor of neurology at McGovern Medical School at UTHealth, said in a press release.
Schulz also led a previous study linking general flu vaccination to a 40% reduction in Alzheimer’s risk.
While the previous research had already linkedgeneral flu vaccinationto a reduction in Alzheimer’s risk, this new study looked specifically at the strength of the dose.
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“The public health department had seen our vaccine research and asked if I could come down to talk to them about it,” said Schulz.“We went through the findings, and they asked if there was a difference with different dosages;I was confused.”
Adults who received the quadruple-strength vaccine had a lower risk of Alzheimer’s than those who received the standard dose.(iStock)
After sorting through data from nearly 200,000 older adults, the team found the adults who received the high-dose vaccine had alower risk of Alzheimer’sthan those who received the standard dose.
Adults in the high-dose group had an almost 55% lower risk than those who weren’t vaccinated, significantly outperforming standard-dose protection.
in womencompared to men, although both groups saw significant benefits.
better dietsor more frequent check-ups.
The study focused on people over 65, so it’s unclear whether getting these shots earlier in life would provide the same level of protection.(iStock)
The researchers also looked at medical records after the fact, rather than followingtwo controlled groupsin real time, which can sometimes result in missing information or biases.
“This is not a cause/effect study,” Siegel reiterated.“We can’t conclude that the flu shot itself causes the effect;it could be something about the people who decide to take this shot.”
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The study also focused on people over 65, so it’s unclear whether getting these shots earlier in life would provide the same level of protection.
“This needs to be further studied, but it is already certainly another reason to take a flu shot,” Siegel added.
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The study was published in the journal Neurology.
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