Unexplained shoulder pain could signal dangerous health condition, doctor warns

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Unexplained shoulder pain could signal a more serious problem, experts warn.

While shoulder pain is often the result of rotator cuff problems, injuries, arthritis, nerve problems, or other orthopedic and muscular issues, it can also be a phenomenon called “referred pain” stemming fromliver cancer. 

Pain in the right shoulder blade has been linked to early signs of the disease, according to the American Cancer Society.

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Published case reports have shown that shoulder pain can be a symptom of hepatocellular carcinoma (HCC), the most common type of primaryliver cancer.

Mark Ashamalla, MD, chief of radiation oncology at Episcopal Health Services in New York, confirmed that liver cancer can sometimes cause pain that is felt in the right shoulder, even though the shoulder itself is completely normal.

man holding his shoulder in pain

While many cases of shoulder pain are the result of orthopedic and muscular issues, it can also be a phenomenon called “referred pain” stemming from liver cancer.(iStock)

“The liver sits high in the right upper abdomen, just under the diaphragm, which is the muscle that helps us breathe,�“If a liver tumor grows large enough or is positioned in a way that stretches the liver’s outer covering or irritates the diaphragm, it can trigger nerves in that area.”

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The brain can then misinterpret those signals and “feel” the pain in the right shoulder or right shoulder blade, even though the problem lies in the liver.“It’s a real symptom, but it is not because anything is wrong with the shoulder joint itself,” Ashamalla noted.

This is not true “phantom pain,” which usually refers to pain felt in a body part that has been amputated or removed, the doctor clarified. 

“The problem is in the liver, but the body’s nerve wiring makes the pain show up in the shoulder.”

Various types of shoulder pain

“Mostshoulder painis caused by far more ordinary things, like muscle strain, arthritis, tendon problems or poor posture,” Ashamalla said.

Typical orthopedic shoulder pain usually occurs after an injury, overuse, sleeping awkwardly, lifting something heavy or repetitive motion, according to the doctor.

“It tends to worsen with certain arm movements, and the shoulder may feel tender, stiff, weak or have a limited range of motion,” he said.“By contrast, referred pain from the liver often does not behave like a shoulder problem.”

doctor addresses man

Published case reports have shown that shoulder pain can be a symptom of hepatocellular carcinoma (HCC), the most common type of primary liver cancer.(iStock)

The doctor listed the following clues that may indicate referred shoulder pain linked toliver cancer. 

  • Pain on the right side, often near the top of the shoulder or around the right shoulder blade
  • Pain that’s not clearly triggered by moving the arm
  • Pain when the shoulder exam itself seems relatively normal
  • Pain that feels more like a deep, dull ache than a sharp mechanical pain
  • Pain that keeps going despite rest or routine treatment
  • Pain that comes with other symptoms likeweight loss, poor appetite, nausea, fatigue, abdominal fullness, abdominal swelling or jaundice (yellowing of the skin and eyes).

Doctor displaying a 3D model of a liver in a clinic.

One of the challenges with liver cancer is that it often causes no early symptoms at all, or only very vague ones, according to the doctor.(iStock)

Ashamalla shared the following liver cancer symptoms that can be subtle and easy to overlook.

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