Needle-free diabetes management could be on the horizon, study suggests

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Oral insulin could one day replace injections for people with diabetes, new scientific discoveries suggest.

Researchers from Kumamoto University in Japan have announced the development of an insulin pill to helplower blood sugar.

For diabetics, insulin is typically administered via injection, but the pill would offer a non-invasive treatment option.

girl puts pill to mouth while holding water glass

Oral insulin could one day replace injections for people with diabetes, new scientific discoveries suggest.(iStock)

The study, published in the journal Molecular Pharmaceutics, tested the delivery of oral insulin by building a carrier peptide called DNP-V.This peptide helps to transport insulin through the small intestine, where protein drug absorption is usually poor.

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Indiabetic mice models, the researchers administered the peptide by mouth with zinc-stabilized insulin, which was formulated with zinc ions to make it more stable, according to the study.

“Insulin injections remain a daily burden for many patients.”

The result was a rapid and significant drop in blood glucose, as well as a sustained (longer-term) decrease.The mice’s blood sugar was reduced to near-normal levels.

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When DNP-V was attached directly to insulin, the results showed enhanced absorption in the intestines and a similar glucose-lowering effect, the researchers noted.

The treatment was effective in differentdiabetes models, significantly reducing blood sugar spikes after meals with just one dose per day.

white mouse held by gloved hand in lab

The study was done in mice, which leaves uncertainty if the treatment will translate to humans.(iStock)

The findings suggest that DNP peptides could serve as flexible, adaptable platforms for delivering large-molecule drugs by mouth, the authors concluded in the study abstract.

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“This technology can simply and effectively convert injectable biopharmaceuticals into orally administrable forms, offering a promising path to practical,patient-friendlyoral therapies,” they wrote.

Although the researchers are optimistic about the findings translating to larger therapeutic models, they noted that the results in mice do not guarantee the same outcome in humans, and that more research is needed.

child gets finger pricked for diabetes

For diabetics, insulin is typically administered via injection to regulate blood sugar levels.(iStock)

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Dr.Marc Siegel commented on this development, noting that oral insulin could make a big difference in healthcare.

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“Insulin use, especially in type 1 diabetes, is sometimes difficult to regulateby injection,�“Oral use would have major advantages.”

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