Experimental vaccine could save thousands of lives per year, scientist claims

Fentanyl has been known to be mixed with other substances, such as marijuana.(iStock)

The main benefit, according to Haile, is that the vaccine would reduce the potential health dangers of fentanyl.

“Respiratory depressionis the primary effect that induces death from this highly potent synthetic opioid,” he said.

Headed for trials

Following successful testing in mice and rats, the first human clinical trial is slated to begin in early 2026 at the Center for Human Drug Research, which is associated with the University of Leiden in the Netherlands.

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“They would feel no effects if they ingest fentanyl — absolutely none.And they would not overdose.”

The small Phase 1 trial will enroll about 40 participants, focusing on safety andimmune response.

After the Phase 1 trial for safety, a Phase 2 trial will test whether the vaccine effectively blocks fentanyl’s effects in humans.

Potential risks and limitations

The primary limitation is that data so far is available only for mouse models, and it’s unknown how effective the vaccine would be in humans.

com/health" target="_blank" rel="noopener">side effectsreported in the animal study, likely because the ingredients of the vaccine are proteins that have already been used in other combinations in humans, so their safety profile is already known.

opioid use disorderwho want to quit using fentanyl. 

It could also be used by first responders and healthcare workers who want to reduce the risk of accidental exposure.

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Military and national security personnel could also benefit from the vaccine, Haile said, as it could help protect against fentanyl and fentanyl-like compounds that have been used as chemical threats.

Finally, parents may be seeking protection forat-risk teensor young adults, as fentanyl has been known to be mixed with other substances, such as marijuana.

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The progress of the vaccine is a “very exciting advance with a huge upside,” a medical expert said.(iStock)

Looking ahead, Haile said this could pave the way for the approval of other anti-drug vaccines, such as cocaine and methamphetamine, which are already in the works.

“If we can tackle the primary ones — fentanyl, cocaine and methamphetamine — we will be saving hundreds of thousands of lives,” he added.

“This is likely to prevent many overdoses where a patient is sedated and stops breathing as a result of fentanyl.”

Dr.�very exciting advance with a huge upside.”

“I am very glad it is now entering human trials.It is beingvery well-studied,�“This is likely to prevent many overdoses where a patient is sedated and stops breathing as a result of fentanyl.”

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The antidote for fentanyl (Narcan) is limited because fentanyl lasts for many hours, but the Narcan (an opioid antagonist) wears off after only a few hours and has to be administered again, Siegel pointed out.

“You want to make sure this vaccine is limited to those really at risk for opioidoverdoses and addictionbecause fentanyl is also a useful pain medication for cancer and a useful agent for anesthesia,” the doctor added.

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