![[aggregator] downloaded image for imported item #18450](https://newsview.top/wp-content/uploads/2026/01/oprah-weight-loss-1-1024x576.jpg "Oprah joins wave of celebrities who revealed dramatic weight loss in 2025")
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FDA approves first GLP-1 pill for weight loss
Marc Siegel joins ‘America’s Newsroom’ to discuss the approval of a GLP-1 pill for weight loss and compares it to injection-based alternatives.
Celebrities have been striving for health in 2025, with many dropping significant amounts of weight — in many cases with the help of GLP-1 medications like Ozempic.
Below are four A-list stars who shared theirweight-lossjourneys this year, with or without the help of prescription drugs.
No.1: Oprah Winfrey
Long-time talk show hostOprah Winfreywas recently featured in an exclusive interview with People magazine, during which she discussed her weight loss and her new book, “Enough: Your Health, Your Weight and What It’s Like to Be Free.”
OPRAH WINFREY ADMITS SHE DRANK 17 SHOTS OF TEQUILA IN ONE NIGHT BEFORE GIVING UP ALCOHOL DUE TO GLP-1
Winfrey, 71, began taking aGLP-1 medicationin 2023 but attempted to quit just six months in to see if she could lose weight without it.Regardless of her diet and exercise routines, the media mogul said she still gained back 20 pounds after stopping the drug.
Oprah Winfrey is pictured in February 2020 (left) and in October 2025 (right).(Steve Jennings/Getty Images;Lanna Apisukh/WWD via Getty Images)
“It’s going to be a lifetime thing,” she shared.“I’m on high blood pressure medication, and if I go off thehigh blood pressuremedication, my blood pressure is going to go up.The same thing is true now, I realize, with these medications.I’ve proven to myself [that] I need it.”
Winfrey revealed that her default weight, at 211 pounds, was not healthy, as she waspre-diabeticand had high cholesterol.
AMERICA’S OBESITY CRISIS MEETS THE OZEMPIC BOOM AS DATA REVEALS GLP-1 HOT SPOTS
The author told People that she injects a GLP-1 weekly, and has also paid out of pocket for friends who could not afford the drug.
Winfrey added that the absence of food noise “has given me a quiet strength that comes with everything I do.Everything is just calmer and stronger.”
Amy Schumer, Meghan Trainor and Oprah Winfrey (left to right) are among the celebrities who have revealed their weight loss in 2025.(Raymond Hall/GC Images;Chris Haston/WBTV via Getty Images;Theo Wargo/Getty Images)
Regardless of GLP-1 access or tolerance, Winfrey encouraged thosestruggling with obesitythat it is “not your fault.”
“I want people to stop blaming [themselves] for genes and an environment [they] can’t control,” she said.“I want people to have the information, whatever you choose to do with it, whether you get the medications, or whether you want to keep dieting.”
No.2: Amy Schumer
Comedian Amy Schumerdropped 50 pounds after being diagnosed with Cushing’s syndrome, a hormonal disorder that can cause extreme swelling, fatigue and potentially fatal complications.
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Schumer’s transformation sparked conversation online, to which she responded in a now-deleted Instagram post that shut down speculation aboutcosmetic enhancements.
“I didn’t lose 30 lbs — I lost 50,” she emphasized on social media, adding that she does not get Botox or filler.
Amy Schumer is pictured in May 2024 at left, and on the right after her weight loss in 2025.(Marleen Moise/WireImage;Amy Schumer/Instagram)
Schumer doubled down that her weight loss was not about her appearance, but aboutstaying alive.She also confirmed that she has used the GLP-1 medication Mounjaro.
“Not to look hot, which does feel fun and temporary,” she said.“I did it to survive.I had a disease that makes your face extremely puffy that can kill you, but the internet caught it and that disease has cleared.”
WHAT TO KNOW ABOUT CUSHING’S SYNDROME, WHICH LED TO AMY SCHUMER’S DRAMATIC WEIGHT LOSS
“Sorry for whatever feeling it’s giving you that I lost that weight,” she added.“I’ve hadplastic surgeryover the years and I use [Mounjaro] … I’m pain-free.I can [play] tag with my son.”
The actress also addressed her shifting hormones, saying that she’s “happy to share more if anyone has any questions about how I’m looking or feeling or where I am in my perimenopause process.”
No.3: Meghan Trainor
“All About That Bass” singer Meghan Trainor has also confronted haters for “body-shaming” her after a dramatic 60-pound weight loss.
MEGHAN TRAINOR BLASTS BODY SHAMERS WHO ‘ATTACK’ HER AFTER 60-POUND WEIGHT LOSS
Trainor recently told “Entertainment Tonight” that she’s “never felt better” and istaking care of her healthfor the first time since having her two children.
Meghan Trainor showed off her dramatic weight loss at the Baby2Baby Gala in November 2025.(Emma McIntyre/Getty Images for SiriusXM;Michael Kovac/Getty Images for Baby2Baby)
“I feel great, and that’s when people attack me,” she said, noting that the criticism is only getting “louder” and “meaner.” Despite the online noise, Trainor emphasized that she’s focused on her well-being.
“I’m taking care of myself,” she reiterated.“I have to find a way to not be affected by that.”
GLP-1 WEIGHT-LOSS MEDICATIONS LINKED TO IMPROVED CANCER SURVIVAL IN CERTAIN PATIENTS
The singer’s health journey began by eliminating gluten and dairy from her diet after finding out that she had a “leaky gut.” The artist also got serious aboutstrength training.
Trainor’s own fitness trainer, Bella Maher of Malibu Bodies, posted before-and-after photos of the pop star on Instagram, revealing how hard she worked before introducing a GLP-1 drug.
“Ozempic works because youeat less food,” she said.“It makes you feel full.So, if you can just do that on your own and get mind over matter, it’s the same.”
Lizzo is pictured in March 2021 (left) and in March 2025 (right).(Jay L.Clendenin/Los Angeles Times via Getty Images;Karwai Tang/WireImage)
Lizzo shared that ending her vegan diet and eating more meat helped her stick to acaloric deficit, since she once consumed “a lot of fake meat,” bread and rice.
“And I had to eat a lot of it to stay full … I was consuming 3,000 to 5,000 calories a day.”
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“For me, when I started eating whole foods, like beef and chicken and fish, I was actually full and not expanding my stomach by putting a lot of … fake things in there that weren’t actually filling me up,” she added.
The Grammy winner revealed that her biggest inspiration for losing weight was to alleviate the intenseback painshe would feel after performing on stage.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
“My body was hurting,” she said.“I want to be Tina Turner.I want to be doing stadium shows when I’m 70.If my back is on this track right now, there’s no way.”
�s Stephanie Giang-Paunon contributed to this report.
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