New study questions whether annual mammograms are necessary for most women

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A new study suggests thatannual mammogramsmay not be the only effective approach for preventing breast cancer.

The research, published in the Journal of the American Medical Association (JAMA), tested a risk-based breast cancer screening approach against standard annual mammography.

The WISDOM randomized clinical trial, led by study authors from universities and healthcare systems across the U.S., considered more than 28,000 women aged 40 to 74 years old, splitting them into a risk-based screening group and an annual mammography group.

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Researchers calculated each woman’s individual riskbased on genetics(sequencing of nine breast cancer genes) and other health factors. 

Woman getting mammogram with radiologist

A new study suggests that annual mammograms may not be the only effective approach for preventing breast cancer.(iStock)

Those who were at the highest risk were advised to alternate between a mammogram and an MRI scan every six months.Patients with elevated risk were told to get an annual mammography and counseling.

Average-risk women were guided to get mammograms every two years, while low-risk individuals were advised to have no screening until they became higher risk or reached age 50.

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The researchers found that risk-based screening did not lead to more advancedcancer diagnoses(stage 2B or higher) compared with annual screening, indicating that it is just as safe as traditional methods.The risk-based approach, however, did not reduce the number of biopsies overall, as researchers had hoped.

Among the risk-based group of women, those with higher risk had more screening, biopsies and detected cancers.Women at lower risk had fewer procedures.

Woman holds breast cancer ribbon

The research, published in the Journal of the American Medical Association (JAMA), tested a risk-based breast cancer screening approach against standard annual mammography.(iStock)

“[The] findings suggest that risk-based breast cancer screening is a safe alternative toannual screeningfor women aged 40 to 74 years,” the researchers noted in the research summary.“Screening intensity matched individual risk, potentially reducing unnecessary imaging.”

“If you don’t measure stage 0, stage 1 or stage 2A cancers, you can’t tell whether personalized screening delays diagnosis in a way that matters for survival andtreatment intensity,�

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